Kaley Cuoco and Katey Sagal previously starred together in 8 Simple Rules, and later reunited in The Big Bang Theory. The duo's first collaboration gave Cuoco her first big role and later a cherished friendship. Sagal enjoyed playing Cuoco's mother and confirmed her fondness for the role during The Big Bang Theory's panel at Comic-Con. In an interview with The List, she admitted maintaining contact with Cuoco, noting they share a profound bond after the tragic loss of John Ritter on 8 Simple Rules. Cuoco reciprocates this affinity, remembering how Ritter taught her about respect and kindness on-set. Suddenly, she was working with Sagal again on The Big Bang Theory, announced during the San Diego Comic-Con panel, and expressed her excitement on Instagram. Steve Molaro, the show's executive producer, shared their enthusiasm. Expectedly, fans warmly accepted their reunion, expressing their approval on social media. The collaboration seems to prove that great chemistry on-set can indeed resonate off-screen.